DiagnosticsInfiltrating Blood-Derived Macrophages Are Vital Cells Playing An Anti-inflammatory Role In Recovery From Spinal Cord Injury In Mice
Although macrophages are known as essential players in wound healing,
their contribution to recovery from spinal cord injury is a subject of
debate.
Using a mouse model of spinal injury, Michal Schwartz and colleagues from
the Weizmann institute of Science, Rehovot, Israel tested the effect of
macrophages on the recovery process after injury and demonstrate an
important anti-inflammatory role for a subset of infiltrating
monocyte-derived
macrophages that is dependent upon their expression of the
anti-inflammatory molecule interleukin-10.
These results suggest that this
subset of
macrophages may have a beneficial effect on spinal cord injuries.
Funding:
MS holds the Maurice and Ilse Katz Professorial Chair in
Neuroimmunology. The work was supported in part by the High Q Foundation,
an NRSAD
award, ERC award, and by IsrALS, given to MS. This work was supported also
by the Israel Science Foundation, given to MS and SJ. SJ was supported by
the MINERVA Foundation and by a joint ISF Bio-Med research grant, and is
the incumbent of the Pauline Recanati Career Development Chair. The
funders
had no role
in study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
Competing Interests:
The authors have declared that no competing interests
exist.
Citation:
"Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice."
Shechter R, London A, Varol C, Raposo C, Cusimano M, et al. (2009)
PLoS Med 6(7): e1000113. doi:10.1371/journal.pmed.1000113
PLoS Medicine