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Clinical Activity Of Neratinib In Combination With Trastuzumab And In Combination With Paclitaxel In Advanced HER-2 Positive Breast Cancer
Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE), today announced
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AARP Endorses Bill To Crack Down On Medicare Fraud Bipartisan Legislation Will Reduce The Billions Lost To Fraud Each Year
AARP announced its endorsement of the
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Protecting The Heart With Glucocorticoid Drugs
Glucocorticoids are steroid hormones that have numerous functions; for example, they regulate the response to stress and suppress inflammation. Synthetic glucocorticoids are used clinically in many situations, most famously to treat asthma, allergies, and autoimmunity. They have also been shown in animals and humans to help protect the heart from the damaging effects of heart attack, and this has been attributed to their anti-inflammatory effects. However, Motoaki Sano and colleagues, at Keio University School of Medicine, Japan, have now determined another mechanism by which glucocorticoids protect rodent hearts from the damaging effects of heart attack. Specifically, glucocorticoids, acting via the glucocorticoid receptor (GR), induced mouse and rat heart muscle cells to produce PGD2, and this was responsible for the ability of glucocorticoids to reduce damage to mouse hearts in both an ex vivo and an in vivo model of heart attack. The authors therefore suggest that GR-selective glucocorticoids might be more beneficial to humans following heart attack than glucocorticoids that activate both GR and the MR protein, activation of which occurs in response to stress and might have unwanted consequences.
Diagnostics

Researchers To Inject People With Diabetes With Cells From Pigs

Researchers are hoping that cells from pigs from a remote group of islands 300 miles from New Zealand could lead to a new treatment for Type 1 diabetes. Some of the pigs have been moved from the islands to mainland New Zealand, where they are being kept in fully enclosed sterile housing. The scientists are trialling the cell transplantation technique on a small group of people with unstable Type 1 diabetes in the hope of stimulating insulin production in their pancreases. Professor Bob Elliott who is running the trial has undertaken two similar studies in the past, one in 1995 and one in 2007. He says one volunteer from the first study continued producing insulin 12 years after transplantation - "proof of principle that this can work," he claims. Dr Iain Frame, Research Director at Diabetes UK, said: "Research into pig cell transplantation has been going on for several years, and is an exciting area of investigation. "However, two previous trials in 1995 and 2007 used only 15 volunteers and this small study will be carried out in just eight people in the first instance. It really is far too early to assume that this research will produce a real and lasting benefit to people with Type 1 diabetes in the near future. We will, however, be watching the progress of this area of research with great interest." Diabetes UK


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