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Smokeless Tobacco Safer Than Smoking
Smokeless tobacco products, as used in Europe and North America, do not appear to increase cancer risk. A large meta-analysis, published in the open access journal BMC Medicine, has shown that snuff as used in Scandinavia has no discernible effect on the risk of various cancers. Products used in the past in the USA may have increased the risk, but any effect that exists now seems likely to be quite small.
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Human Trials Commence Next Year For The First Genetically-Engineered Malaria Vaccine
Walter and Eliza Hall Institute scientists have created a weakened strain of the malaria parasite that will be used as a live vaccine against the disease. The vaccine, developed in collaboration with researchers from the US, Japan and Canada, will be trialled in humans from early next year.
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President Obama Joins In Chorus Of Complaints About CBO Figures
President Barack Obama joins the chorus of Democrats who criticize Congressional Budget Office numbers and claim that their analyses estimates aren"t fair. The criticism comes after the agency provided $1 to $1.6 trillion estimates for two of the Democrats" draft health care reform bills.
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Sleep And Weight Gain: A Molecular Link

There appears to be a link between sleep and weight control, with some studies indicating that sleep disruption can increase weight gain and others that diet affects sleep. Victor Uebele and colleagues, at Merck Research Laboratories, West Point, have now provided further evidence to support this association by showing that T-type calcium channels regulate body weight maintenance and sleep in mice. These data suggest that sleep and circadian treatment approaches may be of benefit in the fight against obesity. Previous studies have shown that mice lacking the CaV3.1 T-type calcium channel have disrupted sleep/wake activity. In this study, the researchers found that these mice were resistant to weight gain when fed a high-fat diet. Consistent with these data, when normal-weight rodents were administered a drug that specifically antagonized T-type calcium channels during their inactive phase they showed increased sleep and were protected from weight gain due to a high-fat diet. Further, when the same drug was given to obese rodents it reduced body weight and fat mass. The authors conclude that the benefits of the drug are likely to be a result of better alignment of feeding patterns and the circadian rhythm, and that targeting T-type calcium channels might provide a new avenue of research for those developing drugs to treat obesity. TITLE: Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice AUTHOR CONTACT: Victor N. Uebele Merck Research Laboratories, West Point, Pennsylvania, USA. View the PDF of this article at: https://www.the-jci.org/article.php?id=36954 Karen Honey Journal of Clinical Investigation


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