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Celleron Therapeutics And Astrazeneca Announce Personalised Medicine Collaboration In Cancer For The Development Of AZ's Leading HDAC Inhibitor
Celleron Therapeutics Ltd, the Oxford UK based specialist in the development of individually targeted cancer medicines, has secured exclusive rights to AstraZeneca plc"s lead histone deacetylase (HDAC) inhibitor (AZD 9468), for global development in conjunction with its proprietary "CancerNav" predictive biomarker platform. "CancerNav" specifically identifies those tumours which are most likely to respond to an individual cancer drug, thereby enabling a highly focussed clinical development and commercialisation programme, based on a closely linked diagnostic and therapeutic "personalised medicine" approach.
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Youths Use Drink Labels To Choose Strongest Drink At Lowest Cost, Australia
Contrary to the industry"s position that visible drink labels will promote responsible drinking, young people are, instead, using these visible standard drink labels to increase or even maximize the amount of alcohol they consume at the lowest cost possible.
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New Culprit Behind Obesity's Ill Metabolic Consequences
Obesity very often leads to insulin resistance, and now researchers reporting in the July 8 issue of Cell Metabolism, a Cell Press publication, have uncovered another factor behind that ill consequence. The newly discovered culprit - a protein known as pigment epithelium-derived factor (PEDF for short) - is secreted by fat cells. They also report evidence to suggest that specifically blocking that protein"s action may reverse some of the health complications that come with obesity.
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Surgical Lessons From The Canadian Field Hospital In Afghanistan

Lessons learned at the Canadian-run military hospital in Kandahar, Afghanistan could help surgeons prepare for civilian disasters, according to a London, Ontario physician who has served two tours at the hospital. Dr. Vivian McAlister is a professor in the Department of Surgery at the Schulich School of Medicine & Dentistry at The University of Western Ontario and a general surgeon at the London Health Sciences Centre. He spent two months working at the Kandahar hospital in 2007 as a civilian surgeon before joining the Canadian Forces and doing a second tour at the hospital this past winter. War surgeons have developed ways to deal with situations where many severely injured patients are brought to hospital at the same time. McAlister says this knowledge would be very useful in civilian hospitals when dealing with catastrophes such as a bus crash on the 401 or a roof collapse in a school. McAlister is preparing a course in catastrophic surgery which will be offered this September at the Canadian Surgery Forum in Victoria, British Columbia, so military surgeons can share these skills with their civilian colleagues. "Combat surgery has taught us to rapidly transport patients to hospital resuscitating them along the way, to expedite life and limb-saving surgery, but then to send patients to the intensive care until their normal physiological status returns before attempting to complete surgery," says McAlister. "More patients have been saved using these techniques known as "damage control resuscitation" than if definitive surgery is done up front." He says combat surgery also incorporates methods to help patients, friends and staff deal with the stress of these awful situations in order to minimize harmful responses. An article by McAlister on the history of military surgery in Canada and how the knowledge gained at the field hospital transfers to civilian hospitals is published in the June issue of the Canadian Journal of Surgery. Kathy Wallis University of Western Ontario


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