Diagnostics
The Wall Street Journal reports: "A plan to end a program that would cut government payments to doctors is emerging as the flash point in the debate over whether President Barack Obama"s effort to overhaul the health system would increase the federal budget deficit. The proposal was crucial to winning support from the politically powerful American Medical Association -- but it has also made it tougher to argue that the health overhaul would pay for itself. ... Health and Human Services Secretary Kathleen Sebelius, appearing on NBC"s "Meet the Press," said costs associated with the legislation could be reduced significantly if lawmakers included the administration"s recommendation to bolster the power of the Medicare Payment Advisory Commission, or MedPAC, to set Medicare payment policies.
Building on its widely distributed multiplex PCR technology platform, Seegene is now providing healthcare systems worldwide with a powerful diagnostic test for effective identification of the new influenza A virus (swine H1N1).
NPR reports that California"s $26.3 billion budget deficit is marginalizing seniors who rely on California state-provided health care and service to help them manage their lives.
London Bridge Hospital, part of the HCA hospitals group, has installed the first Siemens MAGNETOM® Essenza MRI in the UK. The 1.5 Tesla system will complement three other Siemens MRIs currently in use at London Bridge to provide a streamlined, coordinated imaging service.
U.S. Lawmakers Should Not Slow AIDS Funding
The New York Daily News on Friday examined the federal government"s recent actions to remove HIV from the list of diseases that can bar foreign residents from entry into the U.S. According to the Daily News, "The current regulations took effect in 1987, at the height of the worldwide AIDS scare," but, "[n]ow, with the backing of the Obama administration, the ban could be lifted by the end of the year." Martin Cetron, director of the CDC"s Division of Global Migration and Quarantine, said, "We"re trying to end the stigma and the discriminatory practice for a disease that doesn"t warrant exclusion for coming into this country." MSNBC.com reports that "immigration critics say they"re leery of the proposal that could allow an average of 4,275 HIV-infected people into the country annually, with a lifetime medical cost of about $94 million for those admitted during the first year, according to CDC estimates published this month in the Federal Register" (Aleccia, 7/17). Through Aug. 17, CDC is seeking public comment on the proposed rule to remove HIV from the list of diseases that can bar entry into the U.S. (Miller, 7/17).
Ducking a punch or a thrown spear calls for the power of the human brain to process 3-D motion, and to perceive an object (whether it"s offensive or not) moving in three dimensions is critical to survival. It also leads to a lot of fun at 3-D movies.
The individual health insurance market is not a viable option for the majority of uninsured adults, a new report from The Commonwealth Fund finds. Seventy-three percent of people who tried to buy insurance on their own in the last three years did not purchase a policy, primarily because premiums were too high. In addition, among adults with individual coverage or who tried to buy coverage in the past three years, 57 percent said it was very difficult or impossible to find coverage they could afford, 47 percent said it was very difficult or impossible to find a plan with the coverage they needed, and 36 percent were denied coverage or charged more because of a pre-existing condition, or had the condition excluded from their coverage.
As the UK enters a summer of discontent, one company has a vision to make the outlook decidedly brighter - by looking at life through blue-tinted spectacles.
On the occasion of World Hepatitis Day and on the eve of the European Parliament elections, healthcare professionals and patients call on EU decision-makers to make the next 5 years about protecting the liver!
Most women surgeons would choose their career again, although many would favor more options for part-time or other alternative work schedules, according to a report in the July issue of Archives of Surgery, one of the JAMA/Archives journals.
TUMOR IMMUNOLOGY: Killing off human tumor cells
Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN), Eli Lilly and Company (NYSE: LLY) and Alkermes, Inc. (Nasdaq: ALKS) today announced positive results from a study comparing subjects randomized to either exenatide once weekly or Lantus® (insulin glargine). Patients randomized to exenatide once weekly experienced a statistically superior reduction in A1C, a measure of average blood sugar over three months, of 1.5 percentage points from baseline, compared to a reduction of 1.3 percentage points for Lantus after completing 26 weeks of treatment. At the end of the study, patients treated with exenatide once weekly achieved a mean A1C of 6.8 percent compared with a mean A1C of 7.0 percent in those treated with Lantus. Treatment with exenatide once weekly also produced a statistically significant difference in weight, with a mean weight loss of 5.8 pounds at 26 weeks, compared with a mean weight gain of 3.1 pounds for Lantus, a difference of 8.9 pounds between the treatments.
TCGRx (TCG), an industry leader in automation and design services for pharmacy markets across the U.S., announced today the launch of the C-Ray Electronic Pill Counter in the retail pharmacy market.
Placebos are a sham - usually mere sugar pills designed to represent "no treatment" in a clinical treatment study. The effectiveness of the actual medication is compared with the placebo to determine if the medication works.
Johns Hopkins biomedical engineering students have demonstrated a practical way to embed a patient"s own adult stem cells in the surgical thread that doctors use to repair serious orthopedic injuries such as ruptured tendons. The goal, the students said, is to enhance healing and reduce the likelihood of re-injury without changing the surgical procedure itself.
Women in Somerset now have a new of expert information and advice available to them as soon as they know they are pregnant.
Research carried out at the Hebrew University of Jerusalem has resulted in a promising approach to help treat Alzheimer"s disease in a significant proportion of the population that suffers from a particularly rapid development of this disease.
A UK-wide government review has concluded that some asylum seekers whose claims have been refused but who cannot return home should not be denied free NHS treatment. Commenting on the announcement, Dr Vivienne Nathanson, Head of Science and Ethics at the BMA, said:
When cells cannot carry out the tasks required of them by our bodies, the result is disease. Nanobiotechnology researchers are looking for ways to allow synthetic systems take over simple cellular activities when they are absent from the cell. This requires transport systems that can encapsulate medications and other substances and release them in a controlled fashion at the right moment. The transporter must be able to interact with the surroundings in order to receive the signal to unload its cargo. A team led by Frank Caruso at the University of Melbourne has now developed a microcontainer that can hold thousands of individual "carrier units" - a "capsosome". As they report in the journal Angewandte Chemie, these are polymer capsules in which liposomes have been embedded to form subcompartments.
The risk of developing breast cancer due to taking hormone replacement therapy appears to be the same for women with a family history of the disease and without a family history, a University of Rochester Medical Center study concluded.
The American Dental Hygienists" Association (ADHA) recently awarded Minnesota State Senator Ann Lynch with a presidential citation to recognize her extraordinary efforts in passing legislation which will establish new oral health providers in Minnesota.
The Kansas chapter of the National Organization for Women has formed its own political action committee to replace ProKanDo, a PAC founded in 2002 by abortion provider George Tiller that was closed after his murder in May, the AP/Hays Daily News reports. ProKanDo spent more than $1 million over the last four years to advocate for abortion rights, assist candidates who support abortion rights and oppose antiabortion-rights candidates. The organization had more than 6,400 contributors but received between one-third and one-half of its annual funding from Tiller, according to former Director Julie Burkhart.NOW has scheduled a conference in Wichita on July 25 to discuss legislative strategy and Kansas elections. Marla Patrick, coordinator of NOW"s Kansas chapter,÷ said that although the new PAC will not have the same financial support from Tiller that ProKanDo received, his death has invigorated grassroots support. She added, "I think that can be every bit as effective, if not more so, especially in light of all the recent events" (Hegeman, AP/Hays Daily News, 7/18).
Four newspapers recently published editorials responding to last week"s confirmation hearings for Supreme Court nominee Sonia Sotomayor. Summaries appear below.~ Boston Globe: Sotomayor "far surpassed" the "meager standard" of "just [having] to avoid saying anything damaging," according to a Globe editorial. During the hearings, she "made it clear she believes that Supreme Court justices base their decisions on the Constitution, the law and the relevant precedents," and her "judicial record offers no reason to think otherwise," the editorial states. It continues that "the hearings did nothing to undermine -- and much to underscore -- the notion that Sotomayor has the right temperament, intellect and credentials for the Supreme Court. She should be confirmed" (Boston Globe, 7/20).~ New York Times: The Senate "has learned more than enough about [Sotomayor"s] qualifications to give her a seat on the court," according to a Times editorial. However, "[i]t would also be good if senators -- and the nation -- had a deeper sense of her views on some of the most pressing legal questions of our times," the editorial continues. It adds, "We were disappointed that at her confirmation hearings last week, she continued what is becoming an unbreakable habit of nominees dodging controversy." For example, "[w]e would have liked to hear her boldly defend the idea of the Constitution as a living document, one that changes with the times," and "we would have preferred if she had used the hearings to explain to the public that the much-mentioned distinction between judges making and applying the law has little meaning," the editorial states. Sotomayor "avoided saying much of substance about abortion rights, the scope of presidential power, and other hot-button issues," although this is "not entirely her fault," as the "Senate has shown repeatedly that it will tolerate this sort of evasion." However, "the public has a right to know where judicial nominees stand on important legal issues that will have a direct impact on their lives," the editorial states. It concludes, "We hope the Senate confirms her without delay so we can see more clearly what her contribution will be" (New York Times, 7/21).~ Washington Post: During her confirmation hearings, Sotomayor "proved herself well-qualified and worthy of confirmation," according to a Post editorial. The editorial continues, "She spoke convincingly about her belief in and record of consistently respecting legislative prerogatives -- an approach that signals a modest style of judging." Although the hearings focused on Sotomayor defending her previous speeches and comments, her "attempts to explain away and distance herself" from the statement that a wise Latina might make a better decision than a white man "were unconvincing and at times uncomfortably close to disingenuous, especially when she argued that her reason for raising questions about gender or race was to warn against injecting personal biases into the judicial process." The editorial adds, "Her repeated and lengthy speeches on the matter do not support that interpretation." According to the Post, "It"s too bad that she felt she had to disavow her true intent, because, though a wise Latina won"t necessarily judge better than a white man would, diversity on the bench is indeed important" (Washington Post, 7/19).~ Washington Times: During the hearings, Republican senators "failed to ask questions of great relevance to public understanding of the judge"s record and integrity," a Times editorial states. The editorial continues, "They owe it to all Americans to get tough enough to force an examination of whether the judge may have perjured herself during her testimony." According to the editorial, "The questions for which Judge Sotomayor"s answers are almost impossible to believe involved legal briefs on abortion cases that were filed by the Puerto Rican Legal Defense and Education Fund during the 12 years Judge Sotomayor sat on its board." Republican senators also "failed to ask sharp f
The Escambia County Health Department announced that a sentinel chicken from the Riverview
Chrysalis Ventures, a venture capital firm in Kentucky, is looking for health care start-ups that save money and betting that they will get a greater share of health dollars once reform takes shape, The New York Times reports. ""Whatever form health care reform takes, we believe companies that can improve the productivity and efficiency of improvement of health care services and avoidance of medical problems are going to prosper, and we"re putting our money behind that belief," (Chrysalis Ventures Chairman and Managing Director David) Jones said."
The Connecticut legislature used its override in both chambers to undo seven vetoes by the governor, including one to cover most Connecticut residents, called SustiNet, The Hartford Courant reports: "Senate Majority Leader Martin Looney said that healthcare, "in many ways, has become a cloud of worry"" over much of society. SustiNet"s nine-member board of directors will study the issue (covering people and cost) for 17 months before giving its recommendations to the legislature in January 2011" (Keating, 7/20).
The disease onchocerciasis, also known as river blindness, can be eliminated using drugs, according to a WHO study, BBC reports. The disease, which infects about 37 million people worldwide, is caused by a "nematode worm that can live inside the human body for years" and is transmitted to people through the bite of a black fly, the news service writes. The worms spread through the body and when they eventually die, the human immune system "reacts fiercely," which "destroys living tissue - especially the eye," according to BBC (7/21).
John Kofi Agyekum Kufuor, a former president of Ghana, has been named a global ambassador against hunger for the U.N."s World Food Programme (WFP), Xinhua reports. According to the news service, Kufuor will "help to underline the importance of fighting hunger on several fronts - by investing in long-term agricultural development, but also by funding WFP"s work in tackling urgent hunger needs and helping the hungry poor to access affordable and nutritious food" (Ooko, 7/20).
Timeframe before conception may be linked to disease later in life
Yesterday"s 19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) conference in Helsinki reported a significant addition to the dwindling number of drugs in the fight against the hospital "Superbug", Methicillin Resistant Staphylococcus aureus (MRSA).
Discoveries by Scripps Research Institute scientists have led to a promising new drug candidate - the first in its class - for patients with a genetic protein-misfolding disease. In results announced by the biopharmaceutical firm FoldRx Pharmaceuticals, Inc., the new drug tafamidis significantly halts disease progression for patients with a disease called Transthyretin (TTR) amyloid polyneuropathy (ATTR-PN).
Commenting on the Care Quality Commission"s report into the West London Mental Health Trust, NHS Confederation Chief Executive Steve Barnett said:
A sixteen-month study of consensus-based diagnosis of patients with disorders of consciousness has shown that 41% of cases of minimally conscious state (MCS) were misdiagnosed as vegetative state (VS), a condition associated with a much lower chance of recovery. Researchers writing in the open access journal BMC Neurology have demonstrated that standardized neurobehavioral assessment is more sensitive than diagnoses determined by clinical consensus.
A new report aimed at increasing the number of doctors from lower income groups was branded a missed opportunity by doctor and medical student leaders after it failed to address the full of extent of the soaring financial cost of studying medicine in the UK.
Adherence to modifiable lifestyle and dietary factors including maintaining normal weight, daily vigorous exercise, eating a diet high in fruits, vegetables, low-fat dairy products and low in sodium and taking a folic acid supplement was associated with a significantly lower incidence of self-reported hypertension among women, according to a study in the July 22/29 issue of JAMA.
Tobira Therapeutics Inc., a clinical stage biotechnology company committed to research and product discovery for the treatment of life-threatening and life-altering infectious diseases, today announced pharmacokinetic data and results from two Phase I pharmacokinetic studies for TAK-652, an investigational compound being developed for the treatment of HIV. These data suggest that TAK-652 is rapidly absorbed and demonstrate relatively good oral bioavailability (as shown by the plasma TBR-652 concentration data) and has a long plasma half-life of TBR-652 (approximate mean of 35 hours) supporting once-daily dosing. Mean TBR-652 plasma concentrations were well above the predicted target plasma concentration (2ng/mL) with or without food. In both studies TBR-652 was safe and well tolerated in this healthy subject population when administered over a dose range of 10 mg to 800 mg in 2 tablet formulations. "These two Phase I studies provide encouraging support for TAK-652 as a therapeutic option for the treatment of HIV. We look forward to results from our on-going proof-of-concept study," said James Sapirstein, CEO.
AnaSpec has introduced a wide selection of membrane potential fluorescent probes.
An exploratory study to be published in BJOG: An International Journal of Obstetrics and Gynaecology, has shown that women going into early preterm labour (before 34 weeks gestation) have low-levels of progesterone in their saliva as early as 24 weeks, and that moreover, these levels fail to rise during pregnancy in the normal way. This offers the possibility of developing a simple, non-invasive test to identify women at increased risk of delivering early.
The CCA, AIMp, BPSA, and NPA are appealing for an immediate reinstatement of community pharmacists to the Shortage Occupations List after the removal of community pharmacists from the list by the Migration Advisory Committee (MAC) last month.
In an interview with CBS" "Evening News" on Tuesday, President Obama said that lawmakers should "not get distracted by the abortion debate" as they weigh health reform legislation. When asked by "Evening News" anchor Katie Couric if he would "favor a government option that would cover abortions," Obama replied that what he thinks is "important, at this stage, is not trying to micro-manage what benefits are covered." He added that his "main focus is making sure that people have the options of high-quality care at the lowest possible price." Obama also said, "As you know, I"m pro-choice. But I think we also have the tradition of, in this town, historically, of not financing abortions as part of government-funded health care." He continued that "[r]ather than wade into that issue at this point, I think it"s appropriate for us to figure out how to just deliver on the cost savings, and not get distracted by the abortion debate at this station" (Couric, "Evening News," CBS, 7/21).
Women who underwent radiation therapy for cancer as children have an increased long-term risk for developing breast cancer, according to a study published in the Journal of Clinical Oncology, Reuters reports. However, when the childhood treatments included a high dose of radiation to the ovaries, women"s risk of developing future breast tumors was "sharply reduced," according to the study.For the study, Peter Inskip of the National Cancer Institute and colleagues examined 120 women diagnosed with cancer before age 21. All women in the study were treated with radiation between 1970 and 1986 and survived at least five years. The women were compared with four women who also were diagnosed at a young age but did not receive radiation.The study found that the more radiation a woman received as a child, the more likely it was that a tumor would eventually develop. The study did not find that chemotherapy for the first cancer increased the risk for a second cancer (Reuters, 7/20).
Asthma UK"s team of clinical experts is offering important advice on how people with asthma can help protect themselves against swine flu now and into the autumn.
American Indian teenagers become parents at twice the rate of other American teenagers. Many of these teens have greater environmental and behavioral challenges associated with living on reservations, including higher rates of poverty, increased rates of unemployment and school drop-out, higher rates of alcohol and drug abuse, impaired access to healthcare, as well as increased risk of domestic violence and suicide over the general population.
Giving daily antiretroviral syrup to breastfeeding infants or treating their HIV-infected mothers with highly active antiretroviral drugs is safe and effective in preventing mother-to-child HIV transmission through breast milk, a study led by University of North Carolina at Chapel Hill investigators has found.
Labs Are Vital™ announced that a 2009 high school graduate from northern California, Kelly Peterson, is the grand prize winner of its national video contest. High school students around the country submitted their views on video about why careers in the clinical lab sciences are vital.
Employers will hire 22 percent fewer college graduates in 2009 than they did last year, according to the National Association of Colleges and Employers. That means thousands of Pennsylvania college students graduating this spring may be without health insurance coverage due to unemployment or time elapsing before starting a new job.
Scientists in India are reporting successful laboratory tests of a new and potentially safer alternative to silver-based gels applied to the skin of burn patients to treat infections. With names like silver sulfadiazine and silver nitrate, these germ-fighters save lives and speed healing. The researchers describe gel composed of silver nanoparticles - each 1/50,000th the width of a human hair - that appears more effective than these traditional gels. Their study is scheduled for the Aug. 3 issue of ACS" Molecular Pharmaceutics, a bi-monthly journal.
Music, rather than electromechanical valves, can drive experimental samples through a lab-on-a-chip in a new system developed at the University of Michigan. This development could significantly simplify the process of conducting experiments in microfluidic devices.
Simple measures such as good footcare, sight tests and light exercise can help older people live better, Care Service Minister Phil Hope said as he launched the Older People"s Prevention Package.
The increasing incidence of terrorist attacks means that doctors in civilian settings, as well as those in combat operations, need training on blast injuries. The issues surrounding these frequently devastating injuries are discussed in a Seminar published Online First and in an upcoming edition of The Lancet, written by Dr Stephen Wolf, Department of Emergency Medicine, Denver Health Medical Center, Denver, CO, USA, and colleagues.
In a new study published today in the July issue of the journal Cell Host & Microbe, UC Davis researchers report that both amyloid plaques found in the brains of Alzheimer"s patients and structures made by some gut bacteria likely elicit the same response by human immune cells.
New research reveals Brits prefer to rearrange or cancel their summer holiday than go with a friend who has mental illness. The British would prefer to go on their summer holiday with a friend who has a criminal record than go with a friend who has a mental health problem, a new survey as part of the Time to Change campaign [1] has found.
ACCESS PHARMACEUTICALS, INC. (OTC Bulletin Board: ACCP), announced that its European partner, SpePharm, is collecting data from a post approval study of MuGard in head and neck cancer patients undergoing radiation treatment in the UK showing prevention of oral mucositis. In a multi-center study expected to enroll a total of 280 patients, patients are provided with seven weeks of MuGard therapy, and begin using MuGard one week prior to radiation treatment and then throughout the subsequent six weeks of planned therapy. The first 140 patients being treated in this assessment study have been enrolled and treated, and as of the time of the update, none of these patients have experienced any oral mucositis.
The accepted dogma has been that bone-forming cells, derived from the body"s connective tissue, are the only cells able to form the skeleton. However, new research shows that specialized cells in the blood share a common origin with white blood cells derived from the bone marrow and that these bloodstream cells are capable of forming bone at sites distant from the original skeleton. This work, published online this month in the journal Stem Cells, represents the first example of how circulating cells may contribute to abnormal bone formation.
Bioheart, Inc. (OTC Bulletin Board: BHRT) a company committed to delivering intelligent devices and biologics that help monitor, diagnose and treat heart failure and cardiovascular diseases announced today acceptance of MARVEL-1 data for presentation at the Heart Failure Society of America (HFSA) Meeting September 13-16th, 2009 in Boston, Massachusetts.
Experiencing chronic stress day after day can produce wear and tear on the body physically and mentally, and can have a detrimental effect on learning and emotion. However, acute stress -- a short stressful incident -- may enhance learning and memory.
The World Health Organization is reviewing its 2006 guidelines on the use of antiretroviral drugs by HIV-positive pregnant and breastfeeding women because of new evidence that prolonged use can cut the risk of mother-to-child transmission, Reuters reports. Current guidelines recommend that these women receive a short-course antiretroviral regimen. However, a new study released at an international AIDS conference on Wednesday shows that a stronger regimen over a prolonged period significantly lowers the risk of mother-to-child transmission.The study examined 824 pregnant women in Burkina Faso, Kenya and South Africa who received either the standard antiretroviral regimen or a combination of three antiretrovirals. The combination regimen was administered during the last trimester and for a maximum of six months during breastfeeding, according to study leader Tim Farley of WHO"s Department of Reproductive Health. Farley said women who received the combination regimen during pregnancy, delivery and breastfeeding had a 42% lower risk of transmitting HIV to their infants than women given the standard course.Farley added, "The results of this study show an almost twofold reduction in the risk of HIV transmission during the breastfeeding period and also [show] there is no short-term toxicity" to the women or their infants. He said that participants will be monitored for any long-term health effects. WHO is expected to release the updated recommendations by the end of the year (Roelf, Reuters, 7/21).
As healthcare reform becomes an increasing national priority, the American Psychological Association (APA) and YMCA of the USA announced a partnership that provides strategies to help families improve their overall well-being and physical health, and advocates for a comprehensive healthcare system that has a strong approach to chronic disease prevention. The partnership will specifically address the impact individual behaviors such as eating healthy and increasing physical activity can have in reducing risk factors for chronic diseases.
"Several senior House Democrats voiced strong concern Wednesday with a proposal to empower the executive branch to restrain Medicare spending, adding fresh uncertainty to White House efforts to build support for health legislation," The Wall Street Journal reports. "The proposal is being pushed by a coalition of centrist Democrats who are demanding greater steps to control the growth of health-care costs before they consider supporting legislation that would extend health insurance to tens of millions of Americans lacking coverage." Earlier this week, "the centrists struck a tentative deal with top Obama aides and House Energy and Commerce Chairman Henry Waxman (D., Calif.) to add the proposal to health legislation pending on Capitol Hill."
Slashing red tape would allow Australia"s General Practitioners to spend more time caring for patients, AMA President, Dr Andrew Pesce, said today.
Researchers from Rhode Island Hospital"s department of psychiatry propose that the definition for major depressive disorder (MDD) should be shortened to include only the mood and cognitive symptoms that have been part of the definition in the Diagnostic and Statistical Manual of Mental Disorders (DSM) for the past 35 years. Their recommendation would exclude those symptoms that are currently part of the definition that may be associated with medical illness rather than depression. The proposal is based on a study that appears in the July 23 online first edition of the journal Psychological Medicine.
Case Western Reserve University School of Medicine has received a $3.7 million grant from the National Institutes of Health to determine if painful bladder syndrome may be caused by abnormalities in the autonomic nervous system rather than in the bladder itself.
Women who are at risk for heart disease and who are also experiencing menopause symptoms now have an added re a highly specialized clinic in the Division of Cardiology at the Cedars-Sinai Heart Institute. The Advanced Preventive Women"s Clinic at the Women"s Heart Center recently opened and is offering comprehensive cardiac risk assessments designed specifically for women who are in menopause. The clinic also offers menopausal patients state-of-the-art screenings, as well as personalized medicine therapies and counseling, including high-risk hormone counseling.
Too much alcohol often causes trauma, complicates assessment of injury, and interferes with inpatient care. Even though 20 to 37 percent of accident cases in trauma centers are alcohol-related, some trauma patients are reluctant to self report their drinking. A new study has found that testing for alcohol biomarkers - particularly blood alcohol levels (BALs) - can identify high-risk patients admitted to trauma centers who had denied excessive drinking.
Scientists from The Medical College of Wisconsin in Milwaukee, Sangamo Biosciences, Inc., (NASDAQ: SGMO), Sigma-Aldrich Corporation (NASDAQ: SIAL), Open Monoclonal Technology, Inc. (OMT) and INSERM today announced the creation of the first genetically modified mammals developed using zinc finger nuclease (ZFN) technology.
In a commentary published in BJOG: An International Journal of Obstetrics and Gynaecology, doctors discuss the types of information pregnant women would welcome and why the advice provided to women by doctors is considered trustworthy.
Gangrene occurs when tissue dies (necrosis) because its blood supply is interrupted. Gangrene may be caused by an infection, injury, or a complication of a long-term condition that restricts blood circulation. It most commonly occurs in the extremities - the toes, fingers, arms and legs - but internal organs and muscles may also become gangrenous. There are five main types of gangrene: 1. Dry gangrene. 2. Wet gangrene. 3. Gas gangrene. 4. Internal gangrene. 5. Fournier"s gangrene.
A method of reducing the impact or symptoms of anaphylactic shock has been identified by university researchers.
The increased risk of persons with schizophrenia committing violent crime may be largely mediated by co-existing substance abuse problems, according to a study in the May 20 issue of JAMA.
Speaking at a meeting of the New
Cyberonics, Inc. (Nasdaq: CYBX) announced that the U.S. Food and Drug Administration ("FDA") has approved the company"s proposal to amend the protocol of its D-21 post-approval dosing study in depression patients treated with VNS Therapy(TM).
Good vision can be directly correlated with a child"s learning ability. As much as 80% of the learning a child does occurs through his eyes and approximately 1 in 4 school-age children have some type of vision impairment.
The Committee for Medicinal Products for Human Use (CHMP), the scientific committee of the European Medicines Agency (EMEA), has adopted a negative opinion for the use of Erbitux® (cetuximab) in combination with platinum-based chemotherapy for the treatment of patients with epidermal growth factor receptor (EGFR)-expressing, advanced or metastatic non-small cell lung cancer (NSCLC). Merck KGaA is evaluating potential appeal options requesting that the CHMP re-examine data demonstrating clinical relevant benefits to patients.
Sanofi-aventis (EURONEXT: SAN and NYSE: SNY) and its wholly owned subsidiary, BiPar Sciences, announced the initiation of the pivotal Phase III trial for BSI-201 in combination with chemotherapy in patients with metastatic triple-negative breast cancer (mTNBC), defined by tumors lacking expression of estrogen, progesterone receptors and without over-expression of HER2. BSI-201 is a novel investigational targeted therapy which inhibits poly (ADP-ribose) polymerase (PARP1), an enzyme involved in DNA damage repair.
South African President Jacob Zuma and Virgin Group founder and chair Richard Branson "intend [on] establishing a disease control centre in South Africa as soon as next year," SAPA/The Times reports. "Branson said the initiative, expected to be launched by March, would be 50 percent private and 50 percent government funded," the news service writes (7/22).
The following are stories from this week"s 5th International AIDS Society (IAS) Conference on HIV Pathogenesis, Treatment and Prevention meeting in Cape Town, South Africa:
The U.N. Development Program (UNDP) will help fund a three-year program in response to the increase in HIV/AIDS cases in the Philippines, the Manila Bulletin reports. The program aims to help the country combat the spread of the disease and reach the related U.N. Millennium Development Goal (MDG) targets. "The program has five components that aim to develop intervention packages, especially among vulnerable and at-risk groups in rural areas," writes the Manila Bulletin (Sabater, 7/23).
Merck Serono announced that it is seeking a European license for cladribine, its oral therapy that is in late-stage clinical trials for relapsing remitting MS.
UCB announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMEA) has issued a positive opinion recommending that the European Commission grant marketing authorisation for Keppra® as adjunctive treatment of partial-onset seizures in infants and young children aged one month to under four years.
The poorest people in the UK are 2.5 times more likely to have diabetes at any age than the average person, a new Diabetes UK report reveals today. And once they have the condition, those in the most deprived homes are twice as likely to develop complications of diabetes as those in the least deprived.
Researchers are hoping that cells from pigs from a remote group of islands 300 miles from New Zealand could lead to a new treatment for Type 1 diabetes.
Writers of a new report found "limited or suggestive evidence" that exposure to Agent Orange and other chemicals used in the Vietnam War is
African-American adolescents have some of the highest rates of HIV infection in the United States, and efforts to educate them about preventing the disease must include the help of their adolescent peers, new research suggests.
MEDEC - Canada"s Medical Technology Companies - applauds the Ontario Government for its recent decision to add Positron Emission Tomography (PET) Technology to the services covered by the Ontario Health Insurance Plan (OHIP) thereby ensuring that Ontarians have access to PET technology.
Seattle Genetics, Inc. (Nasdaq: SGEN) announced that it has initiated a phase II clinical trial of brentuximab vedotin (SGN-35), an antibody-drug conjugate (ADC), for the retreatment of patients with Hodgkin lymphoma and systemic anaplastic large cell lymphoma (ALCL). This trial is designed to evaluate tolerability and activity when retreating patients who relapse after previously achieving an objective response to brentuximab vedotin.
Merck, Sharp & Dohme (MSD) received a positive opinion from the Committee for Medicinal Products for Human Use (CHMP) recommending expanded marketing authorisation for ISENTRESS® (raltegravir) in combination with other antiretroviral (ARV) medicinal products for the treatment of HIV-1 infection in all appropriate adult patients, including patients starting HIV therapy for the first time (treatment-naç¯ve), as well as treatment-experienced patients. The positive opinion will be reviewed by the European Commission, which grants marketing authorisation to the 27 countries that are members of the European Union (EU), as well as Iceland and Norway.
Nanobiotix, an emerging nanomedicine company, announced exciting preclinical results using its patented nanoXray therapeutics platform to fight tumors. The preclinical study, performed at Institut Gustave Roussy, one of Europe"s leading cancer treatment centers, showed that an intratumoral injection of NBTXR3 nanoparticles and activated via standard radiation therapy led to complete tumor regression in mice at 60 days, compared to zero tumor regression in mice treated with xray only or NBTXR3 only. The study was led by principal investigator, Jean Bourhis, M.D., Ph.D. a prominent radiation oncologist and researcher at Institut Gustave Roussy.
AARP Executive Vice President John Rother issued the following statement in response to recent commentary by Betsy McCaughey in various media outlets on health care reform measures passed or currently being considered by Congress.
Using ultrasound imaging, UQ physiotherapist Dr Julie Hides is helping a world-champion cyclist ride her bike pain free.
The Royal Pharmaceutical Society of Great Britain has published its fourth Pharmacy
A patient centered medical home pilot project that could become a model for South Carolina has completed its first quarter with 1,110 patients enrolled. It is also attracting the attention of S.C. physicians not involved in the program, and S.C. businesses are interested in it as a means to managing their health care costs.
BrainCells Inc., a company leading the scientific research of neurogenesis using its proprietary platform technology to identify novel pathways for the treatment of central nervous system (CNS) diseases, announced results from the first clinical proof-of-concept study of BCI-952, a combination of low dose buspirone and melatonin, for the treatment of major depressive disorder (MDD). The data were presented at NCDEU 2009, a meeting co-sponsored by the National Institute of Mental Health and the American Society of Clinical Psychopharmacology. Neurogenesis is the process by which pre-existing stem cells in the hippocampus of the adult brain produce new brain cells, including neurons.
The most comprehensive analysis yet of the genome of childhood acute myeloid leukemia (AML) found only a few mistakes in the genetic blueprint, suggesting the cancer arises from just a handful of missteps, according to new findings from St. Jude Children"s Research Hospital. The research appears in the July 27 online edition of the Proceedings of the National Academy of Sciences.
Sanofi Pasteur, the vaccines division of sanofi-aventis Group (EURONEXT: SAN and NYSE: SNY), announced that it has shipped the first doses of the 2009-2010 formulation of Fluzone((R)), Influenza Virus Vaccine. Fluzone vaccine is indicated for active immunization in people 6 months of age and older against influenza disease caused by influenza virus subtypes A and type B contained in the seasonal influenza vaccine. Fluzone vaccine is the only vaccine licensed in the United States for children as young as 6 months of age through adults.
The Minnesota Department of Health recently designated Children"s Hospitals and Clinics of Minnesota"s two hospital locations as Level III Trauma Hospitals. Children"s of Minnesota has the sixth busiest pediatric emergency department in the nation with over 84,000 visits per year, and already treats around 450 trauma cases each year. Children"s voluntarily participated in the intense designation process, which included an external review of the hospitals" res and capabilities to care for young trauma patients. Children"s met the required standards of commitment, clinical and equipment res, and staff training.
Investigators at Memorial Sloan-Kettering Cancer Center (MSKCC), along with collaborating teams at the Cleveland Clinic and the University of Michigan, have completed the first large- scale, multi-institutional study of prostate cancer death after standard treatment to remove the prostate since PSA screening has become widely used as a method to screen for the disease.
Newly released Census Bureau data show that even before the current economic recession began in September 2008, population growth among children younger than age one began to decline, the AP/Kansas City Star reports. Between July 2007 and July 2008, the number of children younger than age one in the U.S. increased 0.9%, compared with a record 2.7% increase the previous year. Although births tend to drop during economic downturns as more people decide that they cannot afford to support children, experts said it is not clear why the recent drop began months before the current recession emerged. Stephanie Ventura, a demographer for the National Center for Health Statistics, said that it will be impossible to know what factors contributed to the change until demographic breakdowns are available later this year. The AP/Star reports that increases in teenage births had been driving up birth rates in recent years.Historically, birth rates have declined during poor economic times -- including the recessions of 1973, 1982 and 2001 -- and births dropped nearly 26% during the Great Depression. Mark Mather, an associate vice president at the Population Research Bureau, said, "The economy does matter. If prospects look worse for families, they"re going to be very likely to have fewer kids" (Yen/Wagster Pettus, AP/Kansas City Star, 5/19).
The House on Friday voted 264-153 to approve its fiscal year 2010 Labor-HHS-Education spending bill (HB 3293) after voting on five amendments addressing price and policy issues, CQ Today reports. The bill would appropriate $730.5 billion. The Senate Appropriations Committee is scheduled to begin markup of its version of the bill on July 28.The House voted 183-247 to reject an amendment offered by Rep. Mike Pence (R-Ind.) that would have prohibited family planning funding through the Title X program to Planned Parenthood clinics. The House also voted 211-218 to reject an amendment by Rep. Mark Souder (R-Ind.) that would have stripped language to lift the ban on federal funding for needle-exchange programs. Lawmakers did approve an amendment offered by Rep. Darrell Issa (R-Calif.) to strip $5 million in funding for three NIH grants to study the HIV/AIDS risks associated with alcohol and substance use among sex workers in Asia and alcoholics in Russia (Wolfe, CQ Today, 7/24).
Several newspapers recently published opinion pieces regarding President Obama"s commencement address at the University of Notre Dame. Summaries appear below.~ Cal Thomas, Washington Times: "Put aside the question of whether" Notre Dame should have invited President Obama to speak at its commencement ceremony on Sunday and "[f]ocus, instead, on [his] remarks and whether he is serious, or can be made so, about actually reducing the number of abortions in America," syndicated columnist Thomas writes in a Washington Times opinion piece. "Don"t put aside, however, the argument that there is only one reason to even want to reduce the number of abortions and that is that what is being killed, terminated, evacuated (choose your term) is, in fact, human life," Thomas adds. "In speaking of "original sin," the president hit upon why abortion has been so easily tolerated for so long," he writes, adding that Obama "spoke of "self-interest" and "crass materialism" but did so in the context of economics, not abortion." Thomas reports that Obama called for making adoption ""more available"" and providing ""care and support for women who do carry their children to term."" Thomas notes that Obama"s speech also included "an appeal for discussion and respect for people with different views," which was "a good beginning, but the ending is what counts, and the initial actions of this president when it comes to abortion and stem cell research have not been pro-life" (Thomas, Washington Times, 5/19).~ Tim Rutten, Los Angeles Times: After his commencement address at Notre Dame, "it"s now clear that the president is the rhetorical equivalent of a "money player,"" which is the "kind of competitor who steps up and delivers in the big games," Rutten writes in a Los Angeles Times opinion piece. Notre Dame"s invitation for Obama to speak at commencement and receive an honorary degree "bec[a]me an engine of controversy" because of protests from "reductionists," or conservative Catholics "who insist on bringing the broad sweep of Catholic social morality down to a single issue -- abortion," Rutten writes. However, Obama "negotiated the situation with remarkable ease," Rutten continues, adding that Obama was "speaking … to three audiences far from South Bend on Sunday." The first audience was the "crucial bloc of Catholic voters who seem to be looking for ways to remain in the Democratic Party," he writes. In addition, Obama was speaking to "those Catholic Democrats in public office ... who are under intense pressure from the reductionist bishops in their home dioceses" and to the U.S. Senate, which will likely ask Obama"s Supreme Court nominee about his or her views on abortion during confirmation hearings, Rutten continues. He concludes, "Even in Washington"s charged partisan atmosphere, it will be hard to ignore the president"s call for civility at Notre Dame" (Rutten, Los Angeles Times, 5/20).~ Clarence Page, Chicago Tribune: Obama "appropriately promoted" the "ability of adversaries to work together on mutual interests" in his commencement address, Page writes in a Tribune opinion piece. Page adds that the speech was "classic Obama the pragmatist: Look past ideology, try to ignore disagreements and work together on mutual interests." Obama said that "at some level, the views of the two camps are irreconcilable," Page writes, adding that it is "because Americans hold no values more dear than "life" and "choice."" Page adds that "[i]n the abortion debate, those values clash head-on." However, Obama"s "eloquent come-together oratory enabled him to leave the university like a hero, even though he glossed over the thorny specifics that drive wedges between people of goodwill when words are hammered into law," Page continues. "For now, by focusing on civility, the president apparently hopes to defuse the abortion powder keg long enough to address his higher priorities," Page writes, concluding, "The economy, national security and health care are going to be tough fight
Hope is fading in the House on voting on reform before the August recess as Democrats bicker over details, Roll Call reports: "Majority Leader Steny Hoyer (D-Md.) told reporters Friday that Democratic leaders may push off the health care bill until September if they can"t get it finished within the next two weeks."
"Premiums for small employers have been rising by double-digit increases for a few years, and they don"t have the negotiating power of larger employers," the Hartford (Conn.) Courant reports. This year"s increases are even higher than usual, on top of an economic recession. Connecticut businesses are resorting to drastic measures to preserve employee"s coverage, or are forced to drop it all together.
The Bill & Melinda Gates Foundation will give an additional $80 million to Avahan, a foundation initiative launched in 2003 for HIV prevention programs in India, Bill Gates said on Thursday, the Seattle Times blog, "Business of Giving" reports. Previous foundation commitments to the program, "which involves more than 100 non-profits in six Indian states," total $258 million, the blog writes (Heim, 7/23).
The Washington Post on Sunday featured Washington D.C.,-based Inner Light Ministries, a 16-year-old black community church with about 100 members, where many go "to share their experience of being black and gay, living and loving in a city where HIV and AIDS lurk in epidemic proportions. ò€¦" Some members of the congregation, as well as four of its leaders including Bishop Rainey Cheeks are HIV-positive. Cheeks teaches safe sex as a part of his sermons and the church provides condoms to its members. The article also discusses the stigma associated with HIV among gay black men. "Some men are reluctant to reveal their health status to possible partners for fear of being rejected," according to the Post. "That attitude, Cheeks said, is part of why gay black men in the District are disproportionately affected by HIV and AIDS. And why he has to keep preaching the message of safe sex," the article states (Fears, 7/26).
The Rural Doctors Association of Australia (RDAA) will write to Prime Minister Kevin Rudd this week to invite him to participate in a national "fact finding" tour of rural hospitals, rural practices, health centres and Aboriginal Medical Services.
An innovative nutritional supplement company, who are highly respected around the world for their ground-breaking and pioneering manufacturing technologies, will be showcasing their unique range of products at Hospitalar 2009; the largest healthcare technologies fair in Latin America.
Older patients with diabetes who take antipsychotic medications appear to have an increased risk of hospitalization for hyperglycemia (elevated blood glucose level), especially soon after beginning treatment, according to a report in the July 27 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Near-normal control of glucose beginning as soon as possible after diagnosis would greatly improve the long-term prognosis of type 1 diabetes, concludes a study published in the July 27, 2009, issue of the Archives of Internal Medicine, which updates information about the clinical course of type 1 diabetes. The study also found that the outlook for people with longstanding type 1 diabetes has greatly improved in the past 20 years due to a better understanding of the importance of intensive glucose control as well as advances in insulin formulations, insulin delivery, glucose monitoring, and the treatment of cardiovascular risk factors.
Although macrophages are known as essential players in wound healing,
New research suggests that current regulations have failed to remove misleading information from cigarette packaging, revealing that a substantial majority of consumers believe cigarettes are less hazardous when the packs display words such as "silver" or "smooth," lower numbers incorporated into the brand name, lighter colours or pictures of filters.
The University of Southern Nevada (USN) College of Nursing has been granted provisional approval by the Utah Board of Nursing to begin offering its 18-month Bachelor of Science in Nursing (BSN) program at the university"s campus located 10920 South River Front Parkway in South Jordan.
An Italian research team, publishing in the current issue of Cell Transplantation (18:4), which is now available on-line without charge at http://www.ingentaconnect.com/content/cog/ct, has found that stem cells derived from human placenta may ultimately play a role in the treatment of lung diseases, such as pulmonary fibrosis and fibrotic diseases caused by tuberculosis, chemical exposure, radiation or pathogens. These diseases can ultimately lead to loss of normal lung tissue and organ failure. No known therapy effectively reverses or stops the fibrotic process.
The cause of lung cancer in never-smokers is poorly understood, but a study led by investigators at the Ohio State University Comprehensive Cancer Center and at the National Cancer Institute has identified a molecule believed to play an early and important role in its development.
Eight million Americans are covered by Health Savings Account (HSA)-eligible insurance plans, an increase of more than 31 percent since last year, a new census released today by America"s Health Insurance Plans (AHIP) finds. Health Savings Accounts were authorized starting in January 2004. Since then, AHIP has conducted a periodic census of its members participating in the HSA/high-deductible health plan (HDHP) market.
Health care leaders focused on changing their organization"s approach to patient safety and quality will have an opportunity to learn from their peers at The Joint Commission and Joint Commission Res" "2009 Annual Conference on Quality and Patient Safety: Explore, Enhance, and Energize - Leadership for the Future." The conference, September 14 to 16, in Rosemont, Ill., is supported by the American Hospital Association, the American Medical Association and the American College of Physicians. Joint Commission Res (JCR) is a not-for-profit affiliate of The Joint Commission.