Medical Devices
According to new research* carried out by Lloydspharmacy, the UK"s leading community pharmacy chain, around 2.1million British holidaymakers and travellers are ignoring the need to protect themselves against malaria.
Evidence suggests that outcomes in many clinical settings leave a lot to be desired, which means that research into quality improvement (QI) in clinical care has the potential to greatly improve the lot of patients. Now a study in the journal Medical Care Research and Review published by SAGE suggests that both theoretical and practical improvements in QI effectiveness studies could make these into much more powerful tools for positive change.
Bosentan appears to be a more cost-effective initial treatment option for patients with moderate pulmonary arterial hypertension (PAH), classified as WHO functional class III, than no active intervention.
Thousands of people in England are unaware that they are at risk of developing heart disease due to an undiagnosed genetic condition, says the Royal College of Physicians. Familial hypercholesterolaemia (FH) is an inherited condition causing high levels of LDL cholesterol, and increased risk of coronary heart disease in men in their 50s and women in their 60s. Early treatment with statins has been shown to reduce risk and improve life expectancy to normal.
The Senate Commerce Committee has found that a flawed payment database produced by a UnitedHealth subsidiary and distributed to other major insurance companies has led insurers to underpay millions of out-of-network claims, forcing patients to make up the difference of health care providers" fees, the Wall Street Journal reports. Aetna, Cigna, WellPoint, and other large insurers used the data to calculate their "reasonable and customary" charges. They also provided UnitedHealth"s subsidiary, Ingenix, with historic data about their payments, which became the foundation of ongoing versions of the flawed payment models.
The Massachusetts Department of Public Health yesterday issued a directive recommending that health care providers include written consent for HIV testing in the general permission forms given to patients receiving medical care, the Boston Globe reports. State health care providers typically give patients separate consent forms for HIV testing, a practice health officials say poses as a barrier to HIV testing for patients and their providers. The new Massachusetts recommendation states that HIV testing should be explicitly mentioned on standard general consent forms. Reinforcing a provision in the CDC"s 2006 HIV testing guidelines, the directive also recommends routine HIV testing for all residents age 13 to 64 in health care settings. Patients in Massachusetts must still opt in to HIV testing, whereas the CDC recommends that HIV testing be performed unless a patient opts out, according to the Globe (Cooney, Boston Globe, 6/25).
The number of people killed at work in Britain has fallen to a record low, new figures from the Health and Safety Executive (HSE) reveal.
The Arizona Senate on Tuesday approved two abortion-related bills, including one that would increase requirements for obtaining abortions in the state and one that would increase penalties for performing a certain abortion procedure later in pregnancy, the Arizona Republic reports. The first bill (H.B. 2564), which passed 16-12, would impose a 24-hour waiting period before abortion procedures, require that abortion providers inform patients about risks and alternatives, and increase parental consent requirements for minors. Although the state has had a written parental consent requirement since 2003, the new measure would require that the consent form be notarized (Newton, Arizona Republic, 6/24). According to the AP/Houston Chronicle, the bill also would "allow pharmacists and other health care providers to refuse to hand out emergency contraception on moral or religious grounds" (Davenport, AP/Houston Chronicle, 6/23). The second bill (H.B. 2400) would impose a fine or two-year prison sentence for violating the state"s law banning intact dilation and extraction procedures, which currently is punishable by one year in prison (Arizona Republic, 6/24).Paul Senseman, a spokesperson for Gov. Jan Brewer (R), said that the governor has not decided whether she will sign the bills. Senseman previously has said that Brewer "has a very consistent pro-life record. Republican leaders in the state Legislature have attempted for years to increase abortion restrictions, but former Gov. Janet Napolitano (D) vetoed every measure on the subject" (Arizona Republic, 6/24).Opponents of H.B. 2564 said that it would make it difficult for women to access abortion services, especially for women outside of urban areas who would have to make multiple trips to providers under the waiting period requirement. According to Planned Parenthood, the bill would reduce the number of communities in the state where abortion is available from 10 to three. Supporters of the bill contend that it would better inform women about risks and alternatives to abortion (AP/Houston Chronicle, 6/23).
Hundreds of health care leaders from throughout the state gathered Wednesday evening in Lake George as the Healthcare Association of New York State (HANYS) presented its 30th annual Distinguished Service Award, its highest honor, to New York State"s health care auxiliaries. Since 1979, HANYS has awarded the Distinguished Service Award to individuals who demonstrate their extraordinary commitment to improving health care through service to their community.
Researchers have successfully blocked SIV, the simian version of HIV, using a new technique that could help lead to the development of an effective HIV/AIDS vaccine, the reports. The research, published online in the journal Nature Medicine, was led by Phillip Johnson, chief medical officer at the Children"s Hospital of Philadelphia. The team also included scientists from Nationwide Children"s Hospital in Columbus, Ohio, and the New England Primate Research Center in Boston.Johnson and colleagues developed a genetically altered virus that carried the vaccine candidate and injected it into the muscles of monkeys. The vaccine prompted the muscles to produce a protein that is designed to bind to SIV and prevent it from infecting cells (Goldstein, Philadelphia Inquirer, 5/18). After treating nine monkeys with the vaccine candidate for one month, the researchers injected them with SIV. Six monkeys were not administered the vaccine candidate before being injected with SIV. None of the immunized monkeys developed AIDS, while three showed indications of SIV infection. Researchers detected high concentrations of the proteins in their blood one year later. All six non-immunized monkeys became infected with SIV, and four died during the trial (Schmid, AP/Austin American-Statesman, 5/18). The DNA used in the carrier virus can deliver DNA into the cells of both monkeys and humans, according to the Inquirer. Johnson said that the results of the trials were so encouraging that he plans to request approval from FDA to begin clinical trials in humans, the Inquirer reports. However, he said that there is "no guarantee that things that work in monkeys will work in humans," adding that an HIV/AIDS vaccine could be 10 years away (Philadelphia Inquirer, 5/18). Recent HIV/AIDS vaccine failures prompted the researchers to try a different route that involved "bypassing the natural immune system that was the target of all previous HIV and SIV vaccines candidates," Johnson said. "Some years ago I came to the conclusion that HIV was different from other viruses ... and we might not ever be able to use traditional approaches," he added (AP/Austin American-Statesman, 5/18). Peggy Johnson -- head of the HIV Vaccine Research Branch at NIH"s National Institute of Allergy and Infectious Diseases, which helped fund the study -- said, "As a concept, I think this is very promising." She added, "We need to make the genes as humanized as possible so that the human body doesn"t react to that." According to Peggy Johnson, tests will be needed to prove that the vaccine candidate can protect against sexually acquired HIV (Fox, Reuters, 5/17). Beatrice Hahn, an HIV/AIDS researcher with the University of Alabama-Birmingham, said that the study"s findings indicate that there is "a light at the end of the tunnel," adding, "It shows thinking outside the box is a good idea and can yield results, and we need perhaps more of these nonconventional approaches" (AP/Austin American-Statesman, 5/18). Hildegund Ertl, a virus expert at the Wistar Institute in Philadelphia, said, "It is a very innovative approach but currently, in my mind, still far from clinical use." Ertl added that because most people have been exposed to adeno-associated viruses through cold viruses, they would be "likely to mount an immune response" to the vaccine. According to Phillip Johnson, most people have not been exposed to the strain of the adeno-associated virus that the researchers used as the carrier. He added that they "will be certainly looking at that as part of our Phase I testing in humans" (Philadelphia Inquirer, 5/18).
An enzyme that naturally occurs in the brain helps destroy the mutated protein that is the most common cause of inherited Parkinson"s disease, researchers at UT Southwestern Medical Center have found.
As a woman gets older, physical problems are less likely to influence whether she is sexually active than her partner"s health or interest in sex, according to a new study by researchers at the University of California, San Francisco and Kaiser Permanente.
When faced with patients suffering a heart attack, doctors have two choices: inject them with medication to dissolve the blood clot (fibrinolytic therapy) or insert a small balloon to open the blocked artery (primary percutaneous coronary intervention (PCI)). Guidelines for treating heart attacks are generally based on clinical trials that do not take "real-life" conditions into account. The latest study by Dr. Thao Huynh of the Research Institute of the MUHC analyses these gaps and provides potential solutions to improve treatment of heart attack. Her article was published in the June 23rd issue of Circulation.
The National Center for Atmospheric Research (NCAR) has teamed with the Inter-American Development Bank (IDB) to launch a far-reaching program to help Latin American and Caribbean nations prepare for the impacts of global warming.
The Riley Safety Store at Riley Hospital for Children, the first of its kind in the nation, serves as a model for children"s hospitals across the nation. Recently expanded, the Riley Safety Store provides space to showcase safety products for children and families, as well as offer different "zones" that simulate home settings and provide families with the opportunity to practice installation and use of child safety products prior to purchase.
Joining a prestigious group including Anish Kapoor and Bernardo Bertolucci, acclaimed Shakespearean actor Simon Russell Beale was welcomed as an Honorary Fellow of the Institute of Psychoanalysis at a presentation on Sunday 21 June 2009. The award was made in recognition of Russell Beale"s "contribution to psychoanalysis through his exceptionally thoughtful work as an actor, especially in major Shakespearean roles and through his reflections on them."
The National Autism Association (NAA) along with 12 other organizations launched a campaign this week to spur letter writing and raise awareness about dangerous restraint and seclusion practices in schools. The initiative comes on the heels of the May 19th GAO Report that revealed no federal laws regulating restraint and seclusion in schools, no laws in 19 states, and "widely divergent" laws in remaining states.
Many animals and people experience chronic joint pain. In dogs, a common of joint pain is hip dysplasia, a developmental defect of the hip joint. Implantation of gold into the soft tissues around the hip joints of dogs with dysplasia can relieve pain and lessen stiffness for several years.
A revolutionary new protein stabilisation technique has been developed by scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC) which could lead to 30 per cent more proteins being available as potential targets for drug development opening up exciting possibilities in drug discovery.
The stomach ulcer bacterium Helicobacter pylori is not transmitted through drinking water as previously thought, but rather through vomit and possibly faeces. This is shown in a thesis at the Sahlgrenska Academy, University of Gothenburg, Sweden. It is therefore possible to prevent the spread of the bacterium in developing countries through some fairly simple measures.
With triple digit temperatures expected over the weekend and into early next week, Cal/OSHA urges employers to observe the precautions specified in the heat illness prevention regulation. To ensure compliance Cal/OSHA will have teams of investigators inspecting outdoor employers over the weekend for heat illness prevention requirements. For employees working outdoors, the hot sun with high temperatures can be life-threatening.
Women who have depression symptoms prior to becoming pregnant are at an increased risk for having preterm births, with the risk twice as high for black women as for white women, according to a study in the Journal of Women"s Health, Reuters reports. For the study, Amelia Gavin of the University of Washington and colleagues examined the links between race, preterm birth and pre-pregnancy depressive mood among 555 women. The study used data collected from 1990-1996 as part of a larger, long-term investigation of heart disease risk.Researchers determined that 18.1% of the 249 black women in the study gave birth prior to 37 weeks" gestation, compared with 8.5% of the 306 white women in the study. The study also found that 9.4% of black women had pre-pregnancy symptoms of depressive mood, compared with 7.2% of white women. After researchers accounted for other factors associated with preterm birth, such as body weight and sociodemographic characteristics, black women"s risk remained more than twice that of white women.Gavin said, "The black-white disparity in preterm birth may be in part a consequence of different exposures to depressive mood prior to pregnancy." She said, "Reproductive outcomes must be viewed in light of women"s health over the entire life-course, as well as during pregnancy," adding that the study"s results suggest that "the experience of cumulative health disadvantages or "weathering"" might play a role in increased risk for preterm birth (Hendry, Reuters, 6/25).
Some senators on the Finance Committee said Thursday they"ve moved closer to cutting their health reform bill"s cost to under $1 trillion.
President Barack Obama joins the chorus of Democrats who criticize Congressional Budget Office numbers and claim that their analyses estimates aren"t fair. The criticism comes after the agency provided $1 to $1.6 trillion estimates for two of the Democrats" draft health care reform bills.
The New York Times reports on a proposal for a new health care reimbursement model that offers warranties to patients, a topic also examined in a piece by Francois de Brantes in the journal, Health Affairs. Brantes and co-authors developed a model, called the Prometheus Payment, which offers set fees to providers that "cover all recommended services, treatments and procedures for specific conditions but are also "risk-adjusted" for patients who may be older or frail. The warranty is based on the costs incurred by avoidable complications. In current fee-for-service plans, all costs from these complications are covered by the third party payer, regardless. But in the Prometheus Payment model, half of the costs from avoidable complications must be paid for by the providers themselves. The result, Mr. de Brantes and his co-authors write, is a payment system that offers patients a health care warranty, since "providers win or lose financially based on their actual performance in reducing the incidence of avoidable complications.""
Many people who test positive for HIV are diagnosed late in the course of their infection when treatment might be less effective, according to a report published Thursday in CDC"s Morbidity and Mortality Weekly Report, Reuters Health reports. The report looked at data on people who were diagnosed with HIV from 1996 to 2005 and found that 45 percent had developed AIDS within three years of their initial HIV diagnosis, 38.3 percent within one year and an additional 6.7 percent within the next two years (Reuters Health 6/25). R. Luke Shouse of CDC"s Division of HIV/AIDS Prevention in the National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, said, "This means that they may have unknowingly transmitted HIV. It also means that there is a time when they had HIV when they were not under appropriate medical care, so there are missed opportunities for prevention and care." A separate CDC report also published yesterday found that 22.3 percent of high school students who are sexually active and 12.9 percent of all students have been tested for HIV (Reinberg, HealthDay/KATC.com, 6/25).
July 1, 2009
No time to keep abreast of the most important osteoporosis-related research? Progress in Osteoporosis, the free online journal published by the International Osteoporosis Foundation (IOF) on http://www.iofbonehealth.org/pio provides concise summaries of new research published in the preceding three to four months. The journal is edited by leading osteoporosis researcher and author, Professor Ego Seeman of the University of Melbourne, Australia.
Because tobacco use impairs military readiness, harms the health of soldiers and veterans, and imposes a substantial financial burden on the departments of Defense and Veterans Affairs, these agencies should implement a comprehensive strategy to achieve the Defense Department"s stated goal of a tobacco-free military, says a new report from the Institute of Medicine. DOD should gradually phase in a ban on tobacco use in the military, starting at military academies and officer training programs and among new recruits, the report says. DOD should also stop selling tobacco products in Army and Air Force commissaries -- Navy and Marine Corps commissaries already do not sell them -- and should stop selling them at a discount in military exchanges and other stores. In addition, Congress should allow VA to establish tobacco-free medical centers.
Morbidly obese seniors, age 65 and over, who had laparoscopic gastric bypass surgery lost nearly 76 percent of their excess weight after two years and had low complication rates and short hospital stays comparable to younger surgical patients, according to a new study presented today at the 26th Annual Meeting of the American Society for Metabolic & Bariatric Surgery (ASMBS).
When a patient is diagnosed with metastatic disease the primary site of the cancer is usually, but not always, evident. When the origin of the cancer is not identified it is described as a Cancer of Unknown Primary site, or CUP.
Pharmacy technicians throughout England, Scotland and Wales will be regulated by the Royal
Experimental devices that read brain signals have helped paralyzed people use computers and may let amputees control bionic limbs. But existing devices use tiny electrodes that poke into the brain. Now, a University of Utah study shows that brain signals controlling arm movements can be detected accurately using new microelectrodes that sit on the brain but don"t penetrate it.
Plainview Milk Products Cooperative, Plainview, Minn., is voluntarily recalling instant nonfat dried milk, whey protein, fruit stabilizers, and gums (thickening agents) that it has manufactured over the past two years, because they might be contaminated with Salmonella. The company sells these products to other industry customers, including distributors and manufacturers, who may have incorporated them into their own products. None of Plainview"s products were sold directly to the public.
Medtronic, Inc. announced that DFine Europe GmbH has accepted the terms of a preliminary injunction granted to Medtronic GmbH by a German Competition Court. The preliminary injunction stops DFine Europe GmbH from using certain misleading marketing claims related to Medtronic"s Kyphon® Balloon Kyphoplasty products in Germany.
A research article published in the World Journal of Gastroenterology refers. The research team lead by Dr. Gabriela Beatriz Acosta, observed that the activity of GS was increased in the hippocampus in PH rats. There was a significant decrease in glutamate uptake in both brain areas, which was more marked in the hippocampus. The decrease in glutamate uptake might be caused by deficient transport function and persistent glutamate activity, which is not metabolized. This leads to severe damage in the cells of the central nervous system (CNS), associated with the presence of moderate ammonia concentration in the blood, as observed in this model. These results demonstrated that partial stricture of the portal vein is able to modify normal function in important areas of the rat brain.
The challenge to the Prime Minister by Mark Harper MP, Shadow Minister for Disabled People, to remove Section 141 of the Mental Health Act which strips an MP of their seat in Parliament if detained under the Act for more than six months, and his tabling of an amendment to the Equality Bill on this issue, are both very welcome and long overdue.
Massachusetts-based Catholic hospital system Caritas Christi Health Care on Friday ended its joint venture with the Missouri-based health insurer Centene after Cardinal Sean O"Malley of the Archdiocese of Boston insisted that the relationship linked Catholic hospitals too closely to abortion providers, the AP/San Francisco Chronicle reports (AP/San Francisco Chronicle, 6/27). Under the joint venture, Caritas and Centene created a new company, CeltiCare, which would have insured thousands of low-income Massachusetts residents under Commonwealth Care, the state"s subsidized health care program. Financially troubled Caritas, which was founded by the Archdiocese of Boston, said it will continue to participate as a provider in Commonwealth Care but will no longer be a co-owner of the insurance venture with Centene. Caritas will provide care to patients covered by Centene, as it does for patients covered by other private insurers, but it will not provide any services that violate Catholic teachings, such as abortions or sterilizations. In terminating the joint venture, the archdiocese hopes to appease criticism that Caritas would have profited from abortion and other services provided at non-Catholic medical centers, the Boston Globe reports. According to the archdiocese, O"Malley sought the withdrawal after weeks of consultation with the church-affiliated think tank National Catholic Bioethics Center, in response to harsh criticism from antiabortion-rights groups for not blocking the agreement. The withdrawal is "a vindication of sorts" for O"Malley"s critics, who have argued that it would be wrong for Caritas to enter an agreement with a health insurer that covers abortion care, according to the Globe. Andrea Miller, the executive director of NARAL Pro-Choice Massachusetts, said that Caritas" involvement in the joint venture had raised concern from NARAL because of the Catholic Church"s opposition to abortion rights. She said that although Caritas has withdrawn from the venture, "[t]he question remains: Will the involvement of Caritas Christi health providers negatively affect women"s ability to get timely access to reproductive services, including birth control?" Miller added that NARAL hopes that state regulators "will continue due diligence to ensure that referrals and services are provided in a manner that does not delay access to reproductive health services" (Paulson/Lazar, Boston Globe, 6/27).
Some homeless teenagers in Colorado are getting dental work done for free as part of the economic stimulus that has expanded service to more poor and uninsured, The Associated Press reports.
A new report finds that "a growing global trade in black market cigarettes is killing tens of thousands of people a year, causing massive health problems and costing governments billions of pounds," the Guardian reports.
OptumHealth Inc. announced that it is providing a free help line to people in West Virginia trying to cope with the emotional consequences of the recent floods that hit the region. Staffed by experienced master"s-level behavioral health specialists, the free help line offers assistance to callers seeking help in dealing with stress, anxiety and the grieving process. Callers may also receive referrals to a database of community res to help them with specific concerns, such as financial and legal issues.
The Retail Advisory Board (RAB) of the National Association of Chain Drug Stores (NACDS) met yesterday during the 2009 NACDS Marketplace Conference to discuss social networking opportunities within their businesses.
President Obama on Saturday released a statement marking National HIV Testing Day that urged U.S. residents to get tested for HIV and work toward reducing the spread of the virus, Bloomberg/Arizona Daily Star reports (Bloomberg/Arizona Daily Star, 6/28). Obama said in the statement, "Each of us must take responsibility for reducing our risk of acquiring or transmitting HIV and for supporting affected individuals and communities. This means getting tested for HIV and working to end the stigma and discrimination people living with HIV face." The White House also released a video message with Obama"s statement (White House release, 6/27).
HIV diagnoses among all men in Louisiana declined from 1997 to 2006, but increased in 2007 and 2008 - diagnoses in the New Orleans metropolitan area alone increased by 9 percent from 2007 to 2008, according to the Louisiana Office of Public Health, the New Orleans Times Picayune reports. Of particular concern are the increases among black men in New Orleans. Among black men of all ages, new HIV diagnoses increased by 4 percent from 2007 to 2008, but increased 23 percent for black men age 20 to 24 and 30 percent for those age 45 to 54. The reasons behind the findings are "complex," according to the Times Picayune. Risky sexual behavior, a "declining sense of concern among young people about AIDS and the stubborn cultural stigma of homosexuality in the black community are all believed to be factors," the Times Picayune reports (Sandoval-Griffin, New Orleans Times Picayune, 6/27).
Registered nurses and hospital employees will hold a patient care vigil Tuesday night, at UC Irvine Medical Center (UCIMC), to protest the administration"s retaliatory actions against Ethel Mark, an RN who has worked in the hospital"s cardiac care unit for the last seven years as a model patient advocate. Ms. Mark was informed that she could expect to be terminated by the beginning of July.
It could mean the end of animal testing and eventually even clinical patient drug trials. The Virtual Physiological Human is a 21st century pan-European project that"s gaining momentum and takes a major step forward this week at The University of Nottingham. http://www.vph-noe.eu/
Newly identified gene variants associated with the age at which females experience their first menstrual period and the onset of menopause may help shed light on the prevention of breast and endometrial cancer, osteoporosis, and cardiovascular disease.
Every cell lining the small intestine bristles with thousands of tightly packed microvilli that project into the gut lumen, forming a brush border that absorbs nutrients and protects the body from intestinal bacteria. In the June 29, 2009 issue of the Journal of Cell Biology, Matthew McConnell, Matthew Tyska, and colleagues now find that microvilli extend their functional reach even further using a molecular motor to send vesicles packed with gut enzymes out into the lumen to get a head start on breaking down their substrates.
Researchers from North Carolina State University and Mayo Clinic have developed a computer model that medical doctors can use to determine the best time to begin using statin therapy in diabetes patients to help prevent heart disease and stroke.
The Australian Nursing Federation joined other unions in celebrating the end of WorkChoices.
Recommendations for how the HHS Office of the Secretary will spend $400 million in funds for patient-centered research, also known as comparative effectiveness research, were released by Federal Coordinating Council for Comparative Effectiveness Research (CER). The report, mandated by the American Recovery and Reinvestment Act, is designed to help the HHS Secretary and lawmakers improve the quality of care for patients, and provide patients and doctors the best information possible to make decisions about health care.
A team of researchers has demonstrated that a new method for detecting and quantifying protein biomarkers in body fluids may ultimately make it possible to screen multiple biomarkers in hundreds of patient samples, thus ensuring that only the strongest biomarker candidates will advance down the development pipeline. The researchers have developed a method with the potential to increase accuracy in detecting real cancer biomarkers that is highly reproducible across laboratories and a variety of instruments so that cancer can be caught in its earliest stages.
Ablynx [Euronext Brussels: ABLX], a pioneer in the discovery and development of Nanobodies®, a novel class of antibody-derived therapeutic proteins, announced that it has advanced ALX-0061, a new Nanobody®-based therapeutic programme, into preclinical development for the treatment of autoimmune and inflammatory diseases.
Pancreatitis is often a fatal condition, in which the pancreas digests itself and surrounding tissue. Scientists have previously found that alcohol can trigger the condition by combining with fatty acids in the pancreas, which leads to an excessive release of stored calcium ions. Once calcium ions enter cell fluid in the pancreas it activates digestive enzymes and damages the cells.
UK experts are calling for greater consideration of gastric banding as an option for obese people with type 2 diabetes who need to lose weight. Dr Jonathan Pinkney, diabetologist, and Mr Paul Super, obesity surgeon, initiated this call to action following the recent European label change confirming that weight loss with Allergan"s LAP-BAND [TM] AP System can lead to improvement or remission of type 2 diabetes. The risk of developing type 2 diabetes is increased up to 10 times in obese people and, alarmingly, the UK has the fastest growing rate of obesity in the developed world.
PROLOR Biotech, Inc. (OTC Bulletin Board: PBTH), formerly Modigene Inc., announced that the U. S. Patent and Trademark Office (PTO) has issued two new patents for the company"s long-acting CTP-enhanced human growth hormone (hGH-CTP) and human erythropoietin (EPO-CTP). The patents cover the composition of PROLOR"s proprietary pharmaceutical compounds as well as certain associated methods. PROLOR"s CTP technology is based on a short amino acid sequence, the Carboxyl Terminal Peptide that occurs naturally in humans. When attached to a therapeutic protein, CTP extends the time that the protein is active in the body.
New research suggests that casino workers face a higher risk of heart disease and lung cancer because they work in buildings filled with tobacco smoke.
Somerset Partnership NHS Foundation Trust has announced the appointment of a new Non Executive Director to its Board.
Whether a monkey is looking to the left or merely watching another monkey looking that way, the same neurons in his brain are firing, according to researchers at the Duke University Medical Center.
"Much of the TV advertising on health care so far has focused on the controversial public, or government-run insurance program that Democrats say would compete with private insurers and Republicans say would drive them out of business," but the Laborers" International Union of North America "will begin airing ads in two states Tuesday that deal with an equally explosive issue: Taxing health benefits," USA Today reports. The union will "run the ads at least through Thursday in North Dakota and Montana," home states of "the two most important senators on the issue, Senate Finance Chairman Max Baucus, D-Mont., and Senate Budget Committee Chairman Kent Conrad, D-N.D." The ads reveal the "fine line labor is walking" on health care: "The ads first praise Congress for taking up the health care debate but then criticize an idea that could be included in one draft of the legislation to tax health care premiums" (Fritze, 6/29).
A recent court decision in Black Hawk County, Iowa where a 34-year-old HIV-positive man was sentenced to 25 years in prison and a lifetime of parole for not informing a sexual partner of his status, might lead to a national discussion on state criminal transmission laws, the Iowa Independent reports. Nick Clayton Rhoades pleaded guilty to criminal transmission of HIV, a felony in Iowa, although he did not transmit the virus to his partner. Under state law, "in direct contradiction to its formal title," transmission is not required for a person to be prosecuted - engaging in activity that intentionally exposes others to the body fluids of an infected person could result in prosecution, including kissing, according to the Independent. Some say that such unintended consequences might encourage Iowa and other states to revisit their transmission laws, the article states (Waddington, Iowa Independent, 6/29).
A minimally invasive procedure to treat tendonitis in the rotator cuff of the shoulder provides immediate symptom relief to the patient, according to a study published in the July issue of Radiology. The study found that ultrasound-guided nonsurgical therapy significantly reduces pain from calcific tendonitis of the rotator cuff and restores lasting mobility after treatment.
Neural stem cells represent the cellular backup of our brain. These cells are capable of self-renewal to form new stem cells or differentiate into neurons, astrocytes or oligodendrocytes. Astrocytes have supportive functions in the environment of neurons, while oligodendrocytes form the myelin layer around axons in order to accelerate neuronal signal transmission. But how does a neural stem cell "know" which way it is supposed to develop? On the molecular level receptors of the Notch family play a significant role in this process. So far, only stimulating extracellular ligands of Notch receptors had been described. Biochemists of Goethe University Medical School now describe a long time assumed but not yet identified soluble Notch inhibitor.
Experts are predicting record-breaking temperatures this week, so it"s important to take precautions to ensure that your diabetes remains well-controlled in this extreme weather.
The equipment used for biomedical research is shrinking, but the physical properties of the fluids under investigation are not changing. This creates a problem: the reservoirs that hold the liquid are now so small that forces between molecules on the liquid"s surface dominate, and one can no longer shake the container to mix two fluids. Instead, researchers must bide their time and wait for diffusion to occur.
Treatment with anti-tumor necrosis factor (TNF) agents is recognized as a risk factor for tuberculosis (TB) in patients with immune-mediated inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, Crohn"s disease, psoriatic arthritis and psoriasis. Most TB cases develop as a result of reactivation of a latent TB infection, and health authorities worldwide recommend screening for latent TB and treating patients before initiating anti-TNF treatment. A new study examined cases of TB associated with anti-TNF therapy and found that the risk of TB is higher for patients receiving anti-TNF monoclonal antibody therapy (infliximab or adalimumab) than for those receiving soluble TNF receptor therapy (etanercept). The study is published in the July issue of Arthritis & Rheumatism.
Doctors have reaffirmed their opposition to assisted suicide following a debate at the BMA"s Annual Conference in Liverpool yesterday. Doctors rejected calls from Thameside doctor, Kailash Chand to change legislation to allow the choice of an assisted death by patients who are terminally ill and who have mental capacity.
Glucocorticoids are steroid hormones that have numerous functions; for example, they regulate the response to stress and suppress inflammation. Synthetic glucocorticoids are used clinically in many situations, most famously to treat asthma, allergies, and autoimmunity. They have also been shown in animals and humans to help protect the heart from the damaging effects of heart attack, and this has been attributed to their anti-inflammatory effects. However, Motoaki Sano and colleagues, at Keio University School of Medicine, Japan, have now determined another mechanism by which glucocorticoids protect rodent hearts from the damaging effects of heart attack. Specifically, glucocorticoids, acting via the glucocorticoid receptor (GR), induced mouse and rat heart muscle cells to produce PGD2, and this was responsible for the ability of glucocorticoids to reduce damage to mouse hearts in both an ex vivo and an in vivo model of heart attack. The authors therefore suggest that GR-selective glucocorticoids might be more beneficial to humans following heart attack than glucocorticoids that activate both GR and the MR protein, activation of which occurs in response to stress and might have unwanted consequences.
Schering-Plough Corp., (NYSE: SGP) announced results from the Phase III ENGAGE clinical trial demonstrating that a single injection of corifollitropin alfa, first in the class of sustained follicle stimulants, achieved similar efficacy to recombinant follicle stimulating hormone (rFSH) given once daily for seven days. The ENGAGE data was presented along with data from the Phase III ENSURE trial and the Phase II REALIZE trial at the 25th annual meeting of the European Society of Human Reproduction and Embryology (ESHRE) in Amsterdam, The Netherlands.
There appears to be a link between sleep and weight control, with some studies indicating that sleep disruption can increase weight gain and others that diet affects sleep. Victor Uebele and colleagues, at Merck Research Laboratories, West Point, have now provided further evidence to support this association by showing that T-type calcium channels regulate body weight maintenance and sleep in mice. These data suggest that sleep and circadian treatment approaches may be of benefit in the fight against obesity.
Pfizer Inc announced the discontinuation of the SUN 1122 Phase 3 trial that evaluated Sutent® (sunitinib malate) plus FOLFIRI (irinotecan plus infusional 5-fluorouracil and leucovorin) versus FOLFIRI alone for the first-line treatment of metastatic colorectal cancer (CRC). The independent Data Monitoring Committee (DMC) found that the addition of sunitinib to the chemotherapy regimen FOLFIRI would be unable to demonstrate a statistically significant improvement in the primary endpoint of progression-free survival (PFS) compared to FOLFIRI alone, in this study. No new safety issues were identified.
AMAG Pharmaceuticals, Inc. (NASDAQ:AMAG) announced that the U.S. Food and Drug Administration (FDA) has granted marketing approval for Feraheme™ (ferumoxytol) Injection for intravenous (IV) use as an iron replacement therapy for the treatment of iron deficiency anemia in adult patients with chronic kidney disease. The recommended dose of Feraheme is an initial 510 mg IV injection followed by a second 510 mg IV injection three to eight days later. Feraheme should be administered as an undiluted IV injection delivered at a rate of up to 1 mL/sec (30 mg/sec). The recommended Feraheme dose may be readministered to patients with persistent or recurrent iron deficiency anemia.
After a series of comprehensive research studies and a governmental research initiative, a respected team of radiation biologists and antioxidant scientists at Premier Micronutrient Corporation has developed BioShield-Radiation® - a patented micronutrient formulation specifically designed to address oxidative stress produced by ionizing radiation.
Hard To Treat Diseases (HTDS) Chief Scientist with its Slavica BioChem subsidiary, Dr. Sanja Pekovic provided updates on recent clinical trials with animal subjects in regards to the use of Ribavirin And Tiazofurin for the potential treatment of Multiple Sclerosis (MS).
Because females carry two copies of the X chromosome to males" one X and one Y, they harbor a potentially toxic double dose of the over 1000 genes that reside on the X chromosome.
A multi-national group of investigators, including a scientist at the University of North Carolina at Chapel Hill, has discovered that nearly a third of the genetic basis of schizophrenia may be attributed to the cumulative actions of thousands of common genetic variants. The effects of each of these genetic changes, innocuous on its own, add up to a significant risk for developing both schizophrenia and bipolar disorder.
Tufts dental researchers conducted a three-year follow-up study that examined the stability of a treatment option for receding gums and found that complete root coverage the goal of the surgery had been maintained. This specific tissue regeneration application, developed at Tufts, reduces the considerable pain and recovery time of gum grafting surgery. The case study of six patients is published in the July 2009 issue of the Journal of Periodontology.
Saying that the savings from chronic disease prevention and treatment "can fill the funding gap for health care reform," the New Jersey Partnership to Fight Chronic Disease (PFCD) was joined by key state business leaders in urging federal lawmakers to "take the savings and run" with a health care reform bill that works for all Americans.
Traumatic Brain Injury (TBI) is the single most common cause of death and disability in children and adolescents, according to the Centers for Disease Control. Now, according to a new study by UCLA researchers, the effects of a blow to the head, whether it"s mild or a concussion, can linger for years.
UCB announced that the U.S. Food and Drug Administration (FDA) approved Cimzia®, the only PEGylated anti-TNF (Tumor Necrosis Factor), for the treatment of adult patients with moderately to severely active rheumatoid arthritis (RA). Cimzia® can be dosed at 400 mg initially and at weeks two and four, followed by 200 mg every other week; for maintenance dosing, 400 mg every four weeks can be considered.
In the coming summer months it is estimated that 200,000 young people in Europe will become infected with Chlamydia and most of them won"t know that they are infected. Chlamydia trachomatis, the most common bacterial sexually transmitted infection in Europe, continues to increase in many countries. It affects mostly young adults under 25. The true occurrence of Chlamydia is most likely much higher than the official figures because the majority of the infected do not have clinical symptoms. Surveys in European countries have shown an estimated population prevalence of 5 to 10 % in young people.
Colorado Right to Life and Personhood USA are proposing a 2010 state ballot initiative with a different version of 2008"s defeated "personhood" amendment to the state constitution, the Colorado Springs Gazette reports. The groups intend to submit their proposal to the Colorado Legislative Council this week. In the November 2008 election, 73% of state voters opposed the previous version, known as Amendment 48, which was sponsored by Colorado for Equal Rights.The new version includes modified language that its supporters say will clarify its intent. Rather than defining a person as "any human being from the moment of fertilization," the new version would establish personhood as "every human being from the beginning of the biological development of that human being." The initiative"s sponsors also said that they will be better funded and articulate a clearer message than in 2008, when a college student launched the campaign.According to the Gazette, abortion-rights supporters "weren"t overly concerned" about the new initiative. Jacy Montoya, head of the Colorado Organization for Latina Opportunity and Reproductive Rights, said that the 2008 vote demonstrated that Colorado residents are "uncomfortable with the government and strangers making personal decision for families." Lynn Paltrow, executive director of National Advocates for Pregnant Women, said that the new attempt "gives us another opportunity to explain how personhood amendments threaten all pregnant women, including those going to term" (Barna,Colorado Springs Gazette, 6/29).
Alastair Campbell has won Mind"s Champion of the Year Award for his significant contribution to raising awareness of mental health. He beat fellow nominee and chat show host Paul O"Grady, among other mental health campaigners, to the prestigious award announced yesterday evening.
Now that the warm weather has arrived, there"s nothing like swimming to help cool you off on a hot summer day. The American Red Cross urges everyone to make water safety a priority over the holiday weekend, whether you are taking a dip in the pool, or spending the day at the beach:
The University of Queensland will establish a $2.5million GP Super Clinic at Ipswich that will focus on key local health issues.
The UN is launching, on Wednesday the 1st of July 2009, a ten-day initiative intended to reach out to 10,000
The Australian Medical Students" Association (AMSA) Global Health Conference continues today, with the focus turning towards our own backyard.
Researchers at the Moores UCSD Cancer Center are injecting a modified herpes virus into melanoma tumors, hoping to kill the cancer cells while also bolstering the body"s immune defenses against the disease.
Kuldev Singh, MD, MPH, Professor of Ophthalmology and Director of the Glaucoma Service at the Stanford University School of Medicine, was elected to Chair the Board of the Glaucoma Research Foundation at the Board of Directors Annual Meeting held April 29. The Glaucoma Research Foundation (GRF) is America"s oldest national institution dedicated solely to preventing vision loss from glaucoma.
HCL plc, the UK"s largest health and social care recruitment agency, said the Government"s proposals to reform the NHS by devolving power to frontline professionals and patients will mean a greater need for flexible staffing and more collaboration between the public and private sectors.
Dartmouth researchers have determined that movie characters who smoke, regardless of whether they are "good guys" or "bad guys," influence teens to try smoking. The study, published in the July 2009 issue of the journal Pediatrics, is titled "Adolescent Smoking: Who Matters More, Good Guys or Bad Guys?"
The joint research, funded by the National Multiple Sclerosis Society and the UK MS Society as well as the National Institutes of Health and Howard Hughes Medical Institute, was conducted by scientists at the University of California San Francisco (UCSF) and University of Cambridge and was published in the journal Genes and Development.
The largest study to date of endometriosis in pregnant women has found that the condition is a major risk factor for premature birth, the 25th annual conference of the European Society of Human Reproduction and Embryology heard. Dr. Henrik Falconer, of the Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden, said that his team had found that women with endometriosis also had a higher risk of other pregnancy complications, as well as being more likely to give birth through Caesarean section. The research is published on-line in the journal Human Reproduction*.
After enrolling in Medicare Part D, seniors who previously had limited or no drug coverage spent more on prescriptions and less on other medical care services such as hospitalizations and visits to the doctor"s office, according to a University of Pittsburgh Graduate School of Public Health study. Published in the July 2 issue of the New England Journal of Medicine, the study also found that seniors who had relatively good drug benefits prior to enrolling in Medicare Part D spent somewhat more on prescriptions and, at the same time, increased their spending on other medical care services.
Deputy Minister for Social Services, Gwenda Thomas announced her plans to implement the next phase of the mandatory registration of the Social Care Workforce in Wales in the interest of public protection.
Acura Pharmaceuticals, Inc. (Nasdaq: ACUR) and King Pharmaceuticals, Inc. (NYSE: KG) announced today that the U.S. Food and Drug Administration (FDA) has issued a Complete Response Letter regarding the New Drug Application (NDA) for Acurox (oxycodone HC1, USP and niacin, USP) Tablets CII, an immediate release product intended for the relief of moderate-to-severe pain.
This Saturday 4th July not only marks the beginning of National Transplant Week, but is also Team UK"s last training meet before they jet off to the World Transplant Games in Australia, helping to raise awareness of the ongoing need for organ donors and encourage people to sign up to the Organ Donor register. Lending support for this year"s team in Australia will be David Moorcroft, patron of both the British Transplant Games and Team UK. Moorcroft aims to give his moral support to Team UK, as well as invaluable last-minute tips.
The Wall Street Journal examines how some U.S.-based health care programs are improving their treatment capabilities by learning from strategies used in developing countries. "When doctors running the AIDS clinic at the University of Alabama at Birmingham wanted to increase the number of patients who showed up for treatment, they turned to an unusual place for help: southern Africa," Wall Street Journal writes. By using an AIDS clinic in Zambia as a model, the Alabama clinic was able to decrease its no-show rate "from 31% in 2007 to 18% through June 2009."
A lack of emotional intelligence leads to poor coping strategies and seriously increases the likelihood of self-harm in teenagers, claims a study published yesterday, in the British Journal of Clinical Psychology.
We swim in a sea of information, but filter out most of what we see or hear. New analysis of data from dozens of studies sheds new light on how we choose what we do and do not hear. The study found that while people tend to avoid information that contradicts what they already think or believe, certain factors can cause them to seek out, or at least consider, other points of view.